Reviewed By
Overview
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.8
USERS' SCORE
Good
Based on 43 Reviews
8
Supplement Facts
Serving Size: 1 Veggie Capsule
Amount Per Serving
%DV
Nattokinase (from fibrinase enzymes)
2,000 FU**
†
Top Medical Research Studies
8
We assessed the effects of nattokinase crude extract (NCE) on hepatocellular carcinoma (HCC) growth in mouse models. Our findings revealed that NCE significantly improved survival rates among treated mice and resulted in decreased tumor size. The extract lowered levels of specific proteins associated with cancer progression, further indicating its potential as a treatment option. Overall, we found that NCE leads to both enhanced survival and reduced tumor growth in HCC-bearing mice.
Read More
9.5
We explored a new approach to treat liver fibrosis using a combination of a nanosized iron-locked drug generator and oral nattokinase therapy. This innovative method allows drugs to bypass barriers in the liver, ensuring they reach damaged areas effectively.
By administering iron chelator deferasirox alongside, we witnessed improved drug activation precisely in the liver, leading to significant antifibrotic effects. Remarkably, this strategy not only reversed liver fibrosis but also minimized the toxic effects of iron in the liver.
Our findings could pave the way for similar treatments targeting liver diseases in the future.
By administering iron chelator deferasirox alongside, we witnessed improved drug activation precisely in the liver, leading to significant antifibrotic effects. Remarkably, this strategy not only reversed liver fibrosis but also minimized the toxic effects of iron in the liver.
Our findings could pave the way for similar treatments targeting liver diseases in the future.
Read More
Most Useful Reviews
9
No more pain
138 people found this helpful
Welcomed Relief! I'm a very active 62-year-old male in good health and physical condition. However, I recently suffered severe "burning" pain in the calf muscles of both legs. My doctor informed me that I had developed P.A.D.s (peripheral vascular disease). Though I always walked 3-5 miles daily, the condition made it extremely painful. The doctor advised me to keep walking, hoping the pain would subside. A relative suggested I try Doctors Best, Best Nattokinase. After taking one capsule in the morning and another in the evening, I went for a 4-mile walk the next day and experienced "No more burning pain"! I continue to take two capsules daily.
Read More
9
Symptom-free now
33 people found this helpful
Cleans the arteries! As someone with a history of heart disease symptoms and wishing to avoid coronary bypass surgery, this supplement has been crucial along with vigorous cardio exercise. I was terrified at one point and prepared for the worst. Fortunately, I learnt about fibrinolytic enzymes like nattokinase. By reducing fat intake and taking these supplements, it has worked well. Today, I am symptom-free, and I trust the quality of Doctors Best products.
Read More
9
Relieves leg pain
28 people found this helpful
Following a recommendation for my DVT (deep vein thrombosis), I took Nattokinase alongside anticoagulants. After a year of treatment, despite managing the condition, side effects like inflammation arose. Fortunately, after taking Nattokinase, the redness and pain in my leg decreased significantly within days, and now my mobility has improved dramatically.
Read More
Medical Researches
SCIENTIFIC SCORE
Moderately Effective
Based on 2 Researches
8.8
- All Researches
9.5
We explored a new approach to treat liver fibrosis using a combination of a nanosized iron-locked drug generator and oral nattokinase therapy. This innovative method allows drugs to bypass barriers in the liver, ensuring they reach damaged areas effectively.
By administering iron chelator deferasirox alongside, we witnessed improved drug activation precisely in the liver, leading to significant antifibrotic effects. Remarkably, this strategy not only reversed liver fibrosis but also minimized the toxic effects of iron in the liver.
Our findings could pave the way for similar treatments targeting liver diseases in the future.
By administering iron chelator deferasirox alongside, we witnessed improved drug activation precisely in the liver, leading to significant antifibrotic effects. Remarkably, this strategy not only reversed liver fibrosis but also minimized the toxic effects of iron in the liver.
Our findings could pave the way for similar treatments targeting liver diseases in the future.
Read More
8
We assessed the effects of nattokinase crude extract (NCE) on hepatocellular carcinoma (HCC) growth in mouse models. Our findings revealed that NCE significantly improved survival rates among treated mice and resulted in decreased tumor size. The extract lowered levels of specific proteins associated with cancer progression, further indicating its potential as a treatment option. Overall, we found that NCE leads to both enhanced survival and reduced tumor growth in HCC-bearing mice.
Read More
User Reviews
USERS' SCORE
Good
Based on 43 Reviews
8
- All Reviews
- Positive Reviews
- Negative Reviews
9
No more pain
138 people found this helpful
Welcomed Relief! I'm a very active 62-year-old male in good health and physical condition. However, I recently suffered severe "burning" pain in the calf muscles of both legs. My doctor informed me that I had developed P.A.D.s (peripheral vascular disease). Though I always walked 3-5 miles daily, the condition made it extremely painful. The doctor advised me to keep walking, hoping the pain would subside. A relative suggested I try Doctors Best, Best Nattokinase. After taking one capsule in the morning and another in the evening, I went for a 4-mile walk the next day and experienced "No more burning pain"! I continue to take two capsules daily.
Read More
9
Symptom-free now
33 people found this helpful
Cleans the arteries! As someone with a history of heart disease symptoms and wishing to avoid coronary bypass surgery, this supplement has been crucial along with vigorous cardio exercise. I was terrified at one point and prepared for the worst. Fortunately, I learnt about fibrinolytic enzymes like nattokinase. By reducing fat intake and taking these supplements, it has worked well. Today, I am symptom-free, and I trust the quality of Doctors Best products.
Read More
9
Relieves leg pain
28 people found this helpful
Following a recommendation for my DVT (deep vein thrombosis), I took Nattokinase alongside anticoagulants. After a year of treatment, despite managing the condition, side effects like inflammation arose. Fortunately, after taking Nattokinase, the redness and pain in my leg decreased significantly within days, and now my mobility has improved dramatically.
Read More
9
Improved stamina
20 people found this helpful
Three years ago, I could only work four hours per day due to heart pain and necessitated Nitroglycerin. After starting Nattokinase to help with Lyme disease, I noticed significant improvement—working eight hours with no issues. It has replaced aspirin for me, alleviating stomach irritation. I consider Nattokinase to be miraculous and beneficial for my everyday productivity.
Read More
9
Stability achieved
9 people found this helpful
After having a stroke, the doctors wanted me on warfarin, which I was reluctant to take. However, a cousin, a lab manager, suggested nattokinase to prevent my blood from becoming sticky and forming clots. I have used it for several years; it completely eliminated the light-headedness I was experiencing. I currently take two pills a day, keeping everything stable. It’s not a blood thinner, so there's no risk of excessive bleeding or the need for ongoing kidney or liver tests. I wouldn't be without it.
Read More
Frequently Asked Questions
9
Relieves leg pain
28 people found this helpful
Following a recommendation for my DVT (deep vein thrombosis), I took Nattokinase alongside anticoagulants. After a year of treatment, despite managing the condition, side effects like inflammation arose. Fortunately, after taking Nattokinase, the redness and pain in my leg decreased significantly within days, and now my mobility has improved dramatically.
7.5
Improves circulation
8 people found this helpful
Nattokinase has a preventive effect on elderly health issues. After using it for a few days, I felt lighter and noticed improvements in sleep quality and blood pressure.
9
No more pain
138 people found this helpful
Welcomed Relief! I'm a very active 62-year-old male in good health and physical condition. However, I recently suffered severe "burning" pain in the calf muscles of both legs. My doctor informed me that I had developed P.A.D.s (peripheral vascular disease). Though I always walked 3-5 miles daily, the condition made it extremely painful. The doctor advised me to keep walking, hoping the pain would subside. A relative suggested I try Doctors Best, Best Nattokinase. After taking one capsule in the morning and another in the evening, I went for a 4-mile walk the next day and experienced "No more burning pain"! I continue to take two capsules daily.
9
Stability achieved
9 people found this helpful
After having a stroke, the doctors wanted me on warfarin, which I was reluctant to take. However, a cousin, a lab manager, suggested nattokinase to prevent my blood from becoming sticky and forming clots. I have used it for several years; it completely eliminated the light-headedness I was experiencing. I currently take two pills a day, keeping everything stable. It’s not a blood thinner, so there's no risk of excessive bleeding or the need for ongoing kidney or liver tests. I wouldn't be without it.
9
Post-COVID relief
1 people found this helpful
BENEFICIAL NATTOKINASE! It’s often recommended as a post-COVID supplement due to its role in preventing chronic disease. Nattokinase dissolves fibrin, improving blood flow and preventing clot formations. It’s safe for heart and cardiovascular issues. Since taking it, I noticed an improvement in a "bursting" sensation in my right leg within days post-COVID.
8.5
Thinner blood
1 people found this helpful
I truly appreciate this product. It effectively thins the blood, enhances circulation, and does not harm the liver or cause allergies like pharmaceutical options. I follow a 3-month course with it regularly.
7.5
Better daily routine
18 people found this helpful
After using Serrapeptase, Nattokinase, and Acetyl-L Carnitine for Peyronie's disease, I experienced significant improvement. My doctors found no detrimental effects on my health. Although I maintain a careful diet and exercise, I am confident that these supplements have eased my condition, making my daily life much more manageable.
9
Improved circulation
7 people found this helpful
I took nattokinase for my elderly mother instead of thinner medications based on aspirin. She has very thick blood and vein disease in the "bouquet". I took 1 pill at night for three months. During this time, I never experienced a heart attack (previously stable once a week, and more when it was hot or when the weather was poor). She also mentioned that her legs have started to burn less. I will definitely continue using it.
6
Blood flow improvement
166 people found this helpful
Nattokinase is excellent for blood circulation. I take one capsule daily. When I took higher doses, my circulation improved immensely; I felt warmer in cold weather, but overdosing can lead to bleeding. This powerful enzyme not only enhances oxygen delivery to tissues but also alleviates muscle pain during exercise and reduces lymph viscosity. It has no side effects and is a safer alternative to aspirin for cardiovascular health.
9.5
We explored a new approach to treat liver fibrosis using a combination of a nanosized iron-locked drug generator and oral nattokinase therapy. This innovative method allows drugs to bypass barriers in the liver, ensuring they reach damaged areas effectively.
By administering iron chelator deferasirox alongside, we witnessed improved drug activation precisely in the liver, leading to significant antifibrotic effects. Remarkably, this strategy not only reversed liver fibrosis but also minimized the toxic effects of iron in the liver.
Our findings could pave the way for similar treatments targeting liver diseases in the future.
By administering iron chelator deferasirox alongside, we witnessed improved drug activation precisely in the liver, leading to significant antifibrotic effects. Remarkably, this strategy not only reversed liver fibrosis but also minimized the toxic effects of iron in the liver.
Our findings could pave the way for similar treatments targeting liver diseases in the future.
8
We assessed the effects of nattokinase crude extract (NCE) on hepatocellular carcinoma (HCC) growth in mouse models. Our findings revealed that NCE significantly improved survival rates among treated mice and resulted in decreased tumor size. The extract lowered levels of specific proteins associated with cancer progression, further indicating its potential as a treatment option. Overall, we found that NCE leads to both enhanced survival and reduced tumor growth in HCC-bearing mice.
References
- Sun Q, Yang W, Song Z, Lu H, Shang W, et al. Precisely Controlling the Activation of an Iron-Locked Drug Generator in the Liver Sinusoid to Enhance Barrier Penetration and Reduction of Liver Fibrosis. J Am Chem Soc. 2024;146:33784. 10.1021/jacs.4c11988
- Yan Y, Wang Y, Qian J, Wu S, Ji Y, et al. Nattokinase Crude Extract Inhibits Hepatocellular Carcinoma Growth in Mice. J Microbiol Biotechnol. 2019;29:1281. 10.4014/jmb.1812.12058
